Question 1: Active chronic hepatitis can be induced in which strains of mice that survive neonatal oronasal infection with reovirus3?
Answer: AKR strain mice, PH strain mice, BALB/c mice, and C57BL mice

Question 2: How is the mouse model for cerebral calcification created?
Answer: intracerebral inoculation of suckling mice with cytomegalovirus, CMV

Question 3: What viral agent when infecting mice provides a model for multiple sclerosis?
Answer: Theiler's encephalomyelitis virus (TEMV)

Question 4: Which mouse strains are genetically predisposed to retinal degeneration?
Answer: C3H mice, and CBA strain mice

Question 5: Which mouse strains are susceptible to light-induced, or light-accelerated, retinal degeneration?
Answer: albino mice of any strain

Question 6: Which mouse strain carries an autosomal recessive obese gene and manifests diabetes?
Answer: C57BL mice

Question 7: Which mouse strains are prone to develop arteriosclerosis?
Answer: BALB/cJ mice, and, SWR/J strain mice

Question 8: Which mouse is a model for Diabetes melitus?
Answer: the spiny mouse, (Acomys cahirinus)

Question 9: Which mouse strain is a model for Diabetes insipidus?
Answer: DE strain mice

Question 10: Which mouse strains develop spontaneous type-B reticulum cell  sarcomas, or Hodgkin's disease-like sarcomas?
Answer: C57BL/6 mice, and SJL/J strain mice (note: SJL/J mice have a 90% incidence)

Question 11: Which mouse strains have a high prevalence of mammary tumors?
Answer: C3H mice, A strain mice, and DBA/2 mice

Question 12: Which mouse strains have a low prevalence of mammary tumors?
Answer: AKR strain mice, BALB/c mice, and C57BL mice 

Question 13: Which mouse strains have high prevalence of MMTV-S, or the Bittner virus?
Answer: C3H mice, A strain mice, DBA strain mice and BALB/cfC3H mice 

Question 14: Which mouse strain has a low incidence of MMTV-S, or the Bittner virus?
Answer: C57BL mice

Question 15: Which mouse strains have a high incidence of lymphocytic leukemia?
Answer: AKR strain mice, C3H mice, and C58 mice 

Question 16: Which mouse strain has a very low incidence of lymphocytic leukemia?
Answer: DBA/2 mice

Question 17: Which mouse strain has a high incidence of spontaneous vulvar carcinoma?
Answer: 129/J mice

Question 18: Which mouse strain develops tail hemangiomas and tail sarcomas?
Answer: BALB/c mice

Question 19: Aged mice of which strain are noted for developing blood-filled lymph nodes?
Answer: C3H mice

Question 20: Which mouse strain is prone to develop atrial thrombosis that usually involves the left atrium and auricle, and may be accompanied by amyloidosis?
Answer: RFM strain mice 

Question 21: Which mouse strains have a high incidence of dystrophic mineralization of the heart, especially the right ventricular epicardium?
Answer: BALB/c mice, C3H mice, and DBA/2 mice

Question 22: Which mouse strains have a low incidence of dystrophic mineralization of the heart?
Answer: C57BL mice

Question 23: Which mouse strain can develop dystrophic mineralization in the tongue and cornea?
Answer: DBA strain mice

Question 24: Which mouse strain does not experience epicardial dystrophic mineralization?
Answer: C57BL/6 mice

Question 25: Which mouse strain develops autoimmune hemolytic anemia?
Answer: NZB mice

Question 26: Which mouse strain develops massive lymphadenopathy, associated with proliferation of aberrant T cells
Answer: MRL strain mice; these white mice present with impressively large lymph nodes

Question 27: Which mouse strains develop immune complex glomerulonephritis, similar to systemic lupus erythematosis?
Answer: NZB mice, and NZBXNZWF1 hybrid mice

Question 28: Which mouse strains are a model for Hirschsprung's Disease, or, megacolon, caused by congenital aganglionosis, or lack of a myenteric plexus?
Answer: NZY mice, NZX mice, and the Jax lethal spotted strain, LS/LS



Question 29: Which mouse strain develops liver tumors when fed a diet that is choline-deficient?
Answer: B6C3F1 hybrid mice

Question 30: Which mouse strain develops symmetrical mineral deposits in the thalamus, midbrain, cerebellum, and cerebrum?
Answer: A/J strain mice

Question 31: Which mouse strain develops peripheral neuropathy, with demyelination in the nerves of the hindlimbs?
Answer: C57BL/6 mice

Question 32: Which mouse strain or strains develop dystrophic mineralization in the left ventricular myocardium, skeletal muscles, kidneys, arteries, and lungs?
Answer: old mice of most strains 

Question 33: Which strain of mice has a high prevalence of pulmonary adenomas with aging?
Answer: A strain mice; A strain mice develop a 70% prevalence of pulmonary adenomas by 2 years of age

Question 34: Which strain of mice has a low prevalence of pulmonary adenomas with aging?
Answer: C57BL strain mice; C57BL strain mice develop a 10% incidence of pulmonary adenomas by 2 years of age, in contrast to the 70% prevalence seen in A strain mice 

Question 35: Which mouse strain is prone to develop polycystic kidney disease?
Answer: BALB/c mice

Question 36: Which mouse strain is prone to develop urethral obstruction that leads to hydronephrosis?
Answer: CDF1 mice

Question 37: Which 2 mouse strains serve as models for Niemann-Pick Disease, characterized by the development of foamy histiocytes that contain cholesterol, phospholipids, and sphingomyelin?
Answer: BALB/c mice, and C57BL mice

Question 38: Which mouse strain develops berry, or dissecting type aortic aneurysms?
Answer: Ohno mice

Question 39: Which mouse strains develop monoclonal gammopathies?
Answer: C3H mice, and CBAXDBA/2F1 hybrid mice

Question 40: In which 2 mouse strains do young mice develop primary amyloidosis?
Answer: SM strain mice, and SBL/J strain mice

Question 41: Primary amyloidosis develops in mature mice of which susceptible strain?
Answer: C57BL mice

Question 42: Which mouse strains are highly resistant to amyloidosis?
Answer: BALB/c mice, and C3H mice

Question 43: Which mouse strains develop autoimmune hemolytic anemia?
Answer: NZB mice, and NZBXNZWF1 hybrid mice

Question 44: Which mouse strains develop systemic lupus erythematosis?
Answer: MRL1 strain mice, NZB mice, and NZBXNZWF1 hybrid mice

Question 45: Which mouse strain develops DiGeorge syndrome, or congenital thymic hypoplasia?
Answer: nude mice

Question 46: Which mouse strain develops testicular teratomas?
Answer: 129 mice

Question 47: Which mouse strains develop ovarian teratomas?
Answer: C3H strain mice, and LT/SV female mice

Question 48: Which mouse strain develops muscular dystrophy?
Answer: 129 strain mice

Question 49: Which mouse strain develops epilepsy?
Answer: DBA/2 mice

Question 50: Which mouse strains develop globoid cell, metachromatic, or sudanophilic leukodystrophies?
Answer: Quaking, and Jimpy mutant mice strains

Question 51: Which mouse strains develop Wardenburg syndrome, a condition with varying degree of hearing loss, changes in skin and hair pigmentation, and different colored eyes?
Answer: Waltzer mice, Shaker mice, and Jerker mice

Question 52: Which mouse strains have a high incidence of hematopoietic tumors?
Answer: AKR strain mice, C58 strain mice, SJL strain mice, BALB/c mice, and C57BR/6 mice

Question 53: Which mouse strain develops external hydrocephalus?
Answer: C57BL mice

Question 54: Which mouse strains develop deafness?
Answer: C57BL/6 mice, and LPJ mice

Question 55: Which mouse strain develops ankylosed tibeotarsal bones?
Answer: C57BL/6 mice

Question 56: Which mouse strain was developed by the Japanese as a model for juvenile onset diabetes?
Answer: the nonobese diabetic mouse strain, NOD

Question 57: Which mouse strain shares similarities with Aleutian mink disease and is a model for Chediak-Higashi syndrome in humans?
Answer: the beige mouse... beige mice have no natural killer (NK) cells

Question 58: Which mouse strain is susceptible to gastric ulcers?
Answer: the LAK mouse; (LAK stands for "lymphokine activated killer" cells)

Question 59: Which non-insulin dependant diabetic mouse strain may be a gastric stress ulcer model, independant of diabetes incidence?
Answer: KKAY mice

Question 60: Which mouse strain is prone to develop audiogenic seizures when exposed to sound at 90 to 120 decibels, or 10 to 20 kilohertz?
Answer: DBA/2 strain mice; audiogenic seizures may cause respiratory failure and death

Question 61: Which mouse strain develops exophthalmos due to squamous metaplasia if exposed to ultraviolet light for 7 days?
Answer: C3H mice, HEJ strain mice

Question 62: Atrial thrombosis is common in which group of mice?
Answer: old, retired male BALB/c breeders

Question 63: Which mouse strain is a hypothyroid mutant?
Answer: RF/J strain mice

Question 64: Which mouse strain has a hypoplastic thyroid gland, similar to primary hypothyroidism in man?
Answer: HYT mutant strain mice

Question 65: Which mouse strain develops iris coloboma, which is described as a keyhole-like pupil?
Answer: waltzing mice

Question 66: Which 3 mouse strains are models for Sjogren's syndrome, an autoimmune disease in which autoantibodies cause dry eyes, dry mouth, and most commonly, rheumatoid arthritis?
Answer: NZBXNZW,F1 hybrid mice, non-obese diabetic mice, and NFS/SLD strain mice after thymectomy

Question 67: Which mouse strain is used as an asbestosis model to study pulmonary fibrosis and carcinogenesis?
Answer: BALB/c mice

Question 68: Which mouse strain, when experimentally infected with Leishmania donovani shows histology similar to human visceral Leishmaniasis?
Answer: BALB/c mice

Question 69: Which mouse strain is used as a model for pulmonary fibrosis following intratracheal administration of bleomycin?
Answer: DBA strain mice

Question 70: Which mouse strain has pups born with congenital cleft palates if cortisone is administered during gestation?
Answer: A strain mice

Question 71: A Reye's-like syndrome, characterized by swollen, pale liver and kidneys, has been reported in which strain of mice?
Answer: BALB/c mice, ByJ strain mice

Question 72: Hepatic lesions that resemble changes seen with Reye's syndrome occur in which mouse strain infected with what agent?
Answer: SCID mice infected with mouse adenovirus 1

Question 73: Which mouse strain shows a high prevalence of respiratory tumors in aging mice?
Answer: A strain mice

Question 74: Which mouse strain shows a low prevalence of respiratory tumors in aging mice?
Answer: C57BL mice

Question 75: What is the only mouse strain known to spontaneously develop closed-angle glaucoma?
Answer: DBA/2NNia mice

Question 76: Which rat is a model for mononuclear cell leukemia?
Answer: WF, the Wistar-Furth rat

Question 77: Which rat is a model for spontaneous autoimmune thyroiditis?
Answer: BUF, the Buffalo rat

Question 78: Can you name 2 rats that are models for prostatic adenocarcinoma?
Answer: ACI, the August Copenhagen Irish rat, and COP, the Copenhagen rat

Question 79: Which rat is a model for congenital genitourinary anomalies?
Answer: ACI, the August Copenhagen Irish rat

Question 80: Which rat is a model for inducible transmissible myeloid leukemia?
Answer: BN, the Brown Norway rat

Question 81: Which rat is a model for hydronephrosis?
Answer: BN, the Brown Norway rat

Question 82: Which rat is a model for urinary bladder carcinoma?
Answer: BN, the Brown Norway rat

Question 83: Can you name 2 rat strains that are models for long-term xenobiotic toxicity?
Answer: the Fisher 344 rat, and the Gunn rat

Question 84: Which rat is a model for gerontology?
Answer: the Fisher 344 rat;  note: the F1 hybrid X of the Fisher 344 and the Brown Norway rat is actually a better gerontology model, but it is less utilized 

Question 85: Which rat is a model for juvenile insulin-dependent diabetes melitus?
Answer: the BB/WOR rat.  Note on the name of this strain: In 1974, a mutation that caused diabetes melitus was identified in a closed colony of outbred Wistar rats at Bio-Breeding Labs in Ontario, Canada... the strain was obtained by the University of Massachusetts in Worchester in 1977, hence the current name symbol: Wistar is the background strain, BB is taken from Bio-Breeding Labs, and WOR comes from the University of Massachusetts, Worchester campus. 

Question 86: Which rat is a model for diabetes insipidus?
Answer: the Brattleboro rat

Question 87: Which rat is a model for experimentally-induced multiple sclerosis, and various experimentally-induced autoimmune diseases?
Answer: LEW, the Lewis rat

Question 88: Which rat is a model for myeloma and production of IgG autoantibody?
Answer: the LOU/C rat; (note: in the name symbol, LOU comes from the Catholic University of Louvain in France; within that strain, C was the subline with high immunocytome incidence)

Question 89: Which rat is a model for obesity-resistance and healthy ageing?
Answer: the Wistar rat

Question 90: Which rat is a model for obesity?
Answer: the Zucker rat

Question 91: Which rat is a model for transplantable Morris hepatoma?
Answer: BUF, the Buffalo rat

Question 92: Which rat is a model for spontaneous hypertension and myocardial infarctions?
Answer: SHR, the spontaneously hypertensive rat

Question 93: Which rat is a model for jaundice and kernicterus?
Answer: the Gunn rat

Question 94: Which rat is a model for T-cell deficiency?
Answer: the nude rat

Question 95: Which rat is a model for type 4 hyperlipoproteinemia?
Answer: Obese SHR, the obese spontaneously hypertensive rat

Question 96: Is the SHR spontaneously hypertensive rat an inbred strain, or an outbred stock?
Answer: outbred stock

Question 97: Is the WKY Wistar Kyoto rat an inbred strain, or an outbred stock?
Answer: outbred stock

Question 98: What is the primary research use of the WKY Wistar Kyoto rat?
Answer: the Wistar Kyoto rat is widely used as the normotensive control for the SHR spontaneously hypertensive rat
